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Here Is a Human Being: At the Dawn of Personal Genomics (Inglese) Copertina rigida – 2 nov 2010

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Book by Angrist Misha

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13 di 14 persone hanno trovato utile la seguente recensione
Here is a really great read 20 novembre 2010
Di Marc H. - Pubblicato su
Formato: Copertina rigida
Misha Angrist's "Here is a human being: At the dawn of personal genomics" is a must read for anyone interested in knowing what's in his or her own DNA. I would further highly recommend it to anyone in the medicine or genetics field. This is the personal story of Misha Angrist who became one of the ten individuals that had their entire human genome sequenced through Dr. George Church's Personal Genome Project. This book delves into the humanity of the great question of "what DO I want to know about my DNA?" How comfortable are any of us with the knowledge that our DNA can suggest that we have inherited a predisposition to cancer or some other malady? The author does a wonderful job of approaching these questions from a myriad of ethical, legal, societal, and medical directions in a captivating, first-person narrative. This book has forever changed my views on what I would and would not want to know about my own DNA. What makes this book such a nice read is that it is a story full of fascinating people. Despite the impossibly complex science that goes into determining one's DNA sequence, the book never becomes trapped in technical speak (although the technical terminology, when present, is both accurate and accessible). I have previously read "The genome war" by James Shreeve and I consider this Angrist book to be the next chapter in the ever-unfolding genomic saga of the day.
5 di 5 persone hanno trovato utile la seguente recensione
Interesting Read 12 dicembre 2011
Di RJ Blain - Pubblicato su
Formato: Formato Kindle
I am not someone who reads a lot of science material, at least for pleasure reading, but I found this book to be very interesting. It does more than just talk about science. It talks about the important people behind the sciences, which interest me a lot more than the actual sciences. There is plenty of science in this book, which is (for the most part) very well explained. There were times I found myself doing a little research to have a better understanding of what the sciences were about, but I feel that this book was good for those who don't necessarily want to know everything about the sciences but want to know about the process of how genomics came to the public.

When I started reading this book, I expected something a lot different than what i got, but I feel that this is a good thing. I don't think this book will necessarily appeal to science lovers and researchers; it is light compared to the hefty tomes that more suit those wanting in-depth knowledge of any subject. It covers the basics so that it can be brought to the average person who *isn't* a scientist, which is what appealed to me as I read it.

Best of all, you realistically only need middle or high school level science to understand what is going on in the book, which opens this title to the average teenager, if that sort of research is up their alley. I also like the general message of this book, and how it pursues the potential impact of genomics on base society.
2 di 2 persone hanno trovato utile la seguente recensione
What if you knew your genome sequence? What would it change? 29 luglio 2011
Di PDF - Pubblicato su
A great book by a thoughtful and honest member of the PGP, one of the first people on the planet to have his genome sequenced. Unlike James Watson, a mid-80s legend with most of his life behind him, Misha Angrist is just like you or me - OK, maybe a little bit smarter and a much better writer. He has a wife, kids, a job, health insurance and self doubts. His honest accounting of his decision to become part of the personal genome project, and what he found out from looking at his whole genome feels like the kind of journey of discovery any of us might go through.

If you've wondered what all this "genome" stuff is all about, the author also narrates the human genome project, and how scientists have achieved the capability to affordably sequence a human being. He's met all the big names, the legends, the people on the cutting edge of science and he shares his impressions and interactions.

It's a great book, a fun read, and a journey of introspection for the author and for the reader.
3 di 4 persone hanno trovato utile la seguente recensione
Not bad but i've read better on the subject of personal genomics and gene testing 25 giugno 2011
Di Raina B. - Pubblicato su
Formato: Formato Kindle
While i think this book is written well and def is interesting in parts, I didn't walk away feeling like I gained much. This is in contradiction to another book on the subject I read called 'Outsmart Your Genes' by Brandon Colby, MD. Outsmart Your Genes: How Understanding Your DNA Will Empower You to Protect Yourself Against Cancer, Alzheimer's, Heart Disease, Obesity, and Many Other Conditions In this book the author Dr. Colby, who is both a respected geneticist and a practicing doctor that is one of the key players in this new field of predictive medicine, also discussed personal genomics in-depth throughout his book. But instead of just an overview he actually says exactly how it is useful today for someone like me (and i know nothing about gene testing!). After reading that book I purchased gene tests for both myself and my child through my doctor (because Dr. Colby's book made me understand how and why to do this) and the results really changed my life because something very signifciant was detected and my doctor thinks it may have saved the life of my son.

'Here is a Human Being' however didn't really provide this type of useful info but instead was just an overview and also spoke down about a lot of things so it made it seem like gene testing was useless whereas i can tell you from personal experience it is not. I guess maybe this book wasn't meant to really give me actionable info but after reading 'Outsmart Your genes' i felt that i not only already learned what i needed to know about the topic and was aware of some of the issues with gene testing but also i knew exactly how it applied to me today and how i could use it to protect my life.
13 di 20 persone hanno trovato utile la seguente recensione
Missed opportunity 27 febbraio 2011
Di Massimo Pigliucci - Pubblicato su
Formato: Formato Kindle
[Excerpt from a full review to appear in Skeptical Inquirer magazine]

Largely, the book is about (unintentionally, I'm sure) the incredible amount of narcissism characterizing most of the people involved in various aspects of the new quest for personal genomics, from scientific luminaries-become-embarrassments like James Watson to people (including Angrist himself) volunteering for the Harvard-sponsored Personal Genome Project. It's a tale of good science mixed with a dangerously careless attitude about personal privacy, to which of course you have to add quite a bit of private financial interests on behalf of a number of startup companies that stand to profit handsomely if they can convince us (and our doctors, who typically know little of genetics) that we really ought to be able to read our annotated genomes online (or maybe on an iPhone app). ... In the course of his quest, Angrist discovered many more largely useless, but highly scientific, facts about his health: his risk of colon cancer is 5%, probably not statistically different from the population average of 6%; he has almost twice the population's risk of Graves' disease, an autoimmune condition caused by an hyperactive thyroid. But there is nothing he can do about it, since the condition is currently incurable, and he shouldn't worry too much about it anyway, because his actual chances of getting it are only 0.93% (free advice: never trust two digit precision after the decimal point in this sort of data). But if he is a normal human being, he probably will fret about anything for which his genomic profile deviates from the average (which, I bet, is not likely to help is natural self-admitted propensity for depression), and his health insurance company will likely take advantage of even statistically insignificant deviations to save a buck at the cost of making his life more difficult. ... I am certainly not advocating hard core skepticism toward personal genomics, this isn't astrology or homeopathy. But it is precisely the sort of complex subject matter -- at the interface among basic science, applied science, technology, business, informatics and, last but certainly not least, ethics -- that should have inspired an equally complex and nuanced book. Alas, Here is a Human Being is not that book.