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Mutants: On Genetic Variety and the Human body (Inglese) Copertina flessibile – Deckle Edge, gen 2005

3.0 su 5 stelle 1 recensione cliente

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Descrizione prodotto


"Combines meticulous historical research, [and] brand-new genetic understanding to tell an absorbing tale." —Matt Ridley, author of Genome

"A marvelous accomplishment. A good look a the amazing prospect before us as we decode the human genome..." —The Seattle Times


Visit Armand Marie Leroi on the web:

Armand Marie Leroi has lived in South Africa, Canada, and the United States. Since 1996, he has been a lecturer in evolutionary genetics at Imperial College, London. He has published widely in technical journals on evolutionary and developmental genetics and writes occasionally for the London Review of Books.

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Dettagli prodotto

  • Copertina flessibile: 431 pagine
  • Editore: Penguin USA (P); Reprint edizione (gennaio 2005)
  • Lingua: Inglese
  • ISBN-10: 0142004820
  • ISBN-13: 978-0142004821
  • Peso di spedizione: 318 g
  • Media recensioni: 3.0 su 5 stelle  Visualizza tutte le recensioni (1 recensione cliente)
  • Posizione nella classifica Bestseller di Amazon: n. 148.567 in Libri in altre lingue (Visualizza i Top 100 nella categoria Libri in altre lingue)
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Formato: Copertina flessibile Acquisto verificato
Il testo passa in rassegna diversi "tipi" di freaks, analizza la possibile origine clinica e gli aspetti mitologici e archetipali. Ma le immagini sono pochissime e di scarsa definizione. Il testo vale comunque.
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Le recensioni clienti più utili su (beta) 4.3 su 5 stelle 66 recensioni
5.0 su 5 stelle not just another book with pictures of 'freaks' 27 febbraio 2014
Di Lizardhaven - Pubblicato su
Formato: Copertina flessibile Acquisto verificato
my family (the family i raised, not my parents) is one that always got every book we could find on circus 'freaks' and human anomalies. why? i am not sure, but in recent years as i have tried to work out the genetics of giants and bigfoot, etc, i have constantly found perhaps the only information available about the population genetics of the rarer pockets of human variety.

while this book has the familiar cover with drawings of the skeletons of mutated humans, the author has done what the older books could never do-tell what mutation on the DNA has caused the problem. it is generally a mutation that occurs within the first cell divisions of a developing fetus.

his chapter on gender presents cases of children raised as female who at puberty suddenly become male. he relates the histories of a young french girl named Marie who lept over a style and had a penis fall out.

several tribes in the world have an abnormally high incidence of this occurring. when such a child is born, they raise it first as a girl, understanding that at puberty it will become a boy.

the author discusses the spotted hyena which made the defect into a functioning population with some rather gnarly nasty bits.

if you are a person who wants to know about this sort of thing, i do not think there is another book that offers what this one does.
1 di 1 persone hanno trovato utile la seguente recensione
4.0 su 5 stelle Excellent Read...with 1 or 2 Provisos 14 gennaio 2014
Di David S. Wellhauser - Pubblicato su
Formato: Formato Kindle Acquisto verificato
It was a very good book, perhaps a little overly technical but a very informative read. The style was elegant but dry.

If you are interested in genetic variations and mutations [the different types of mutations as well] then this is a book you should read.

If, however, you are a casual reader that does not want to have to work to hard with a book then you'll be wanting to give this book a pass.

As other reviewers had noted, this is not a book for pregnant women or women planning on have a family.

Recommended for like the Science without the condescension.

Some vocabulary is specialized but is often explained and what isn't explained is readily available online.
5.0 su 5 stelle Great Book! 12 agosto 2014
Di Jason Foss - Pubblicato su
Formato: Copertina flessibile Acquisto verificato
I ordered this book because I am interested in science, but especially genetics. This book is a great one for anyone who wants to know why some people can be completely different from others. I'm a college student studying biology and genetics right now so this was an interesting read for me. I explained what it was about to my roommate and he decided to read this book when I was done. Some of the chapters have a very scientific and technical vocabulary, but if you have a basic background in science then you should be able to figure out what most things mean. After taking some classes in this kind of stuff I still didn't know what some of the terms were so this was a great book to teach me new things about a topic I love. I would definitely recommend this book to anyone who has a love for science.
4 di 4 persone hanno trovato utile la seguente recensione
4.0 su 5 stelle Very well written- a mixture of genetics, antropology, history, philosphy 1 aprile 2006
Di C. Collins - Pubblicato su
Formato: Copertina flessibile Acquisto verificato
This is a very readable book, only getting too technical once or twice, but for the most part fully explaining concepts for his readers.

Leroi bases his study of mutations in human beings on the philosophy of Francis Bacon. Bacon helped establish the principles by which the scientific inquiry of the natural world was to be conducted. Bacon saw that natural history can be divided intot he study of normal nature, aberrant nature, and nature manipulated by man. Leroi writes: "Centureies ahead of his time, Bacon recognized that the pursuit of the causes of error is not an end in itlsef, bur rather just a means. The monstrous, the strange, the deviant, or merely the different, he is saying, reveal the laws of nature. And once we know those laws, we can reconstruct the world as we wish."

The range of Leroi's knowledge is considerable. The story repeatedly drew together the fields of philosophy, anthropology, history, and molecular biology.

Leroi is the one of the first to discuss that in Africa the Delta 32 polymorphism of the CCR5 gene is currently increasing in frequency because it confers resistance to HIV. We know that CCR5 in some lucky persons of Northern European background gives them some protection against HIV infection. However this trait is so rare among Africans that I suspect the increase will not make significant changes in the grim outlook for sub-Saharan Africa.

The book is actually hopeful even though it discusses the many ways that we as humans can go genetically 'wrong'. Leroi states: "The aveage newly conceived human bears three hundred mutations that impair its health in some fashion."

Leroi's historic studies add much to the book. He uncovers the range of enlightened thinkers who saw human mutations, not as the work of the devil, but as opportunity to study God's methods. For example he quotes Montaigne: "Those whom we call monsters are not so with GOd, who in the immensity of his work seeth the infinite forms therein contained."

Of course there are times that the book makes your hair stand on end. For example: "In 1982, a thirty-five-year-old Chinese man was reported with a parasitic head embedded in the right side of his own head. The extra head had a small brain, two weak eyes, two eyebrows, a nose, twelve teeth, a tongue and lots of hair. When the main head pursed its lips, stuck out its tongue or blinked its eyelids, so did the parasitic head; when the main head ate, the parasite drooled...A Dutch child born in 1995 had the remains of twenty-one foetuses (as determined by a leg count) embedded in its brain."

There is a very interesting case study of the artist Henri de Toulouse-Lautrec. "By the time he was seven his mother had taken him to Lourdes, where she hoped to find a cure for some vaguely described limb problem... By the age of ten he was complaining of constant severe pains in his legs and thighs, and at thirteen minor falls caused fractures in both femurs which, to judge from the length of time during which he supported himself with canes, took about six months to heal. He would use a cane nearly all his adult life. Laurterc also undertwent some unusual facial changes. He developed a pendoulous lower lip, a tendency to drool, and a speech impediment rather like a growling lisp, and his teeth rotted while he was still in his teens."

The examples continue to build on each other, offering new inforamtion and insight throughout the book.
4 di 4 persone hanno trovato utile la seguente recensione
5.0 su 5 stelle At play in the genetic casino 18 aprile 2005
Di ealovitt - Pubblicato su
Formato: Copertina flessibile Acquisto verificato
"Mutants" is part side-show and part genetic crapshoot where the mutated gene almost always loses. The author states that on the average, 300 mutations burden each newly conceived embryo. Five of the mutations won't make it into the general population because of miscarriage and childhood deaths---"No one leaves the genetic casino unscathed." Being born with three sets of eye-lashes, an extra set of ears on one's neck, or in my case, crooked little fingers, are very benign mutations compared to what can and sometimes does go wrong.

The primary theme of this elegant, engaging book is that mutations are the signposts that can be used to determine exactly where in the morphogenesis of an infant, something went physically or genetically astray.

Chapter 1, "A Perfect Join (On the invisible geometry of embryos)" takes the reader on a tour through the first few hours and days of a fertilized egg. Conjoined twins are an example of what can go wrong with the developmental mechanics within the womb. One unfortunate baby was born with 21 partially developed twins (determined through a leg count) in his skull. However, the main thrust of this chapter, using conjoined twins as an example of the process gone wrong, is the search for an 'organizer': that which informs the cells what to do, what to become, and where to go. It is a process that is part mechanical, part chemical, and part sheer dumb luck. As the author puts it: "The power of cell-cell adhesion to mould the developing body is startling."

In the next chapter, the author examines the powerful homeotic genes and signaling proteins such as 'sonic hedgehog,' employing some gruesome examples of what can go wrong during the formation of the neural tube and other body parts. Human and animal Cyclops, as well as other mutations such as 'mermaids' are outcomes of control processes gone wrong. Sonic hedgehog-defective infants have a single cerebral hemisphere, hence one eye. "Mice in which the sonic hedgehog gene has been completely disabled have malformed hearts, lungs, kidneys and guts. They are always stillborn and have no paws..."

I certainly wouldn't recommend this book to a pregnant friend. It's frightening enough to have a vague notion of what might go wrong, without this author's meticulous gene-by-gene guide as to the results of many mutations.

Limb buds, skeletons, growth, gender, and skin color are all viewed in turn, through the distorting lens of genes gone wrong. We are introduced to pigmies, piebalds, cretins, and castrati.

The penultimate chapter, "The Sober Life (on Ageing)" is especially interesting because ageing is something we all do regardless of our original mutational burden. The author raises the interesting question as to whether death is just another genetic engineering problem. "Were it not for ageing's pervasive effects, 95 per cent of us would celebrate our centenaries; half of us would better the biblical Patriarchs by centuries and live for more than a thousand years."

Sir Peter Medawar was the first to suggest that mutations causing fatal errors in old age are not necessarily selected against. Once we've bred and raised our children, what use has nature for us?

The final chapter, "Anthropometamorphosis (an Epilogue)" ends rather wistfully with a discussion of beauty, and why it may be important for the survival of a species. Beauty is defined as the absence of imperfections: "the machine errors that arise from the vicissitudes of the womb, childhood, maturity and old age, that are written all over our bodies and that are so ubiquitous that when we see someone who appears to have evaded them, however fleetingly, we pause to look with amazed delight."

Read "Mutants" and you may also find yourself pausing, and looking about with amazed delight. Armand Marie Leroi does not exploit freaks of mutation so much as he weaves them into the story of each of our individual lives.